Fate of trichloroethylene in the animal body.
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Fate of trichloroethylene in the animal body.

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Published .
Written in English


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Edition Notes

Thesis (M.A.) -- University of Toronto, 1938.

The Physical Object
Pagination1 v.
ID Numbers
Open LibraryOL15973505M

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Orally administered trichloroethylene is readily absorbed into the systemic circulation. In rats dosed with [36 Cl]trichloroethylene by stomach tube (60 mg/kg), 90% to 95% of the radiolabel was recovered in expired air and urine (Daniel ).Administration of a range of doses of labeled trichloroethylene (, mg/kg) to rats and mice yielded peak blood concentrations in 1 hour in mice and.   Role of Metabolism in TCE Toxicity. A broad and complex range of relevant information for assessing human health effects of TCE is available. Previous reviews have found TCE to adversely affect the central nervous system (Bale et al. ), liver (), kidney (Lash et al. b), immune system (Cooper et al. ), and reproductive systems and developing embryo/fetus ().Cited by: The chemical compound trichloroethylene is a halocarbon commonly used as an industrial is a clear non-flammable liquid with a sweet smell. It should not be confused with the similar 1,1,1-trichloroethane, which is commonly known as chlorothene.. The IUPAC name is rial abbreviations include TCE, trichlor, Trike, Tricky and iations: TCE. In animal studies, the nephrocarcinogenic effects of trichloroethylene were more pronounced in male rats than in female rats and were absent in male and female mice. Studies on trichloroethylene metabolism in rodents and in humans indicate a bioactivation role in the development of nephrocarcinogenicity.

Trichloroethylene (TCE) is a chemical used to make refrigerants and as a metal degreaser. It may be found in contaminated soil or water near military bases and in some commercial and household cleaning products. TCE exposure may cause kidney cancer and increase the risk of lymphoma and liver cancer.   Agency for Toxic Substances and Disease Registry Trichloroethylene Toxicity Case Studies in Environmental Medicine (CSEM) Acknowledgements We gratefully acknowledge the work that the medical writers, editors, and reviewers have provided to produce this educationalFile Size: KB. Trichloroethylene (TCE) is a nonflammable, colorless liquid with a somewhat sweet odor and a sweet, burning taste. It is used mainly as a solvent to remove grease from metal parts, but it is also an ingredient in adhesives, paint removers, typewriter correction fluids, and spot removers. exposed to trichloroethylene. (13) Animal studies have reported increases in lung, liver, kidney, and testicular tumors and lymphoma from inhalation and oral exposures in rats and mice. (1,4,13) EPA does not currently have a consensus classification for the carcinogenicity of trichloroethylene.

TRICHLOROETHYLENE IN THE BODY • Trichloroethylene enters the body when you breathe air or drink water containing it • Trichloroethylene can also enter the body through your skin • Most of the trichloroethylene that enters the body is removed in urine within a day KNOWN HEALTH EFFECTSFile Size: KB. Major sites of distribution are the liver and body fat. 26 The liver is a target organ toxicity for trichloroethylene in experimental animals. Data for humans are limited. 27 Case reports describe trichloroethylene induced hepatitis and liver necrosis. 28 Guzelian et al. described both hepatic necrosis and fatty metamorphosis. 29 As early as in. Animal studies have reported effects on the liver, kidney, and CNS from chronic inhalation exposure to tetrachloroethylene. (1, 2) EPA has calculated a Reference Concentration (RfC) of milligrams per cubic meter ( mg/m 3) based on neurotoxicity in occupationally-exposed adults. The RfC is an estimate (with uncertainty spanning. H.M. Mehendale, in Comprehensive Toxicology, Trichloroethylene (Trichloroethene) Trichloroethylene, a common industrial solvent used for degreasing metals, is produced in the United States at about metric tons per year. In addition to being present at industrial sites, trichloroethylene is a contaminant at many chemical waste sites.